Remove the contents of download folders from multiple terminal server users.
Tested and working on Windows Server 2012
Get-ChildItem C:Users*Downloads* | Remove-Item
To remove folders within the download folders, and to stop it throwing exceptions when it comes across them add the Recurse flag
Get-ChildItem C:Users*Downloads* | Remove-Item -Recurse
It won’t delete files that are currently open with the users, so either rebooting the terminal server, or just logging everybody off will solve that.